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Article

Integrating genome-wide association and transcriptome prediction model identifies novel target genes for osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Dec 2021

Zhu M, Yin P, Hu F, Jiang J, Yin L, Li Y, Wang S

Abstract excerpt

In this study, we integrated large-scale GWAS summary data and used the predicted transcriptome-wide association study method to discover novel genes associated with osteoporosis. We identified 204 candidate genes, which provide novel clues for understanding the genetic mechanism of osteoporosis and indicate potential therapeutic targets. INTRODUCTION: Osteoporosis is a highly polygenetic disease characterized by...

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Identifiers

PMID: 34142171
DOI: 10.1007/s00198-021-06024-z
PMCID: PMC8608767

Genes

HSP90B1
MAP2K5
NFATC4
SLC11A2

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