Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causal genes for osteoporosis: Mendelian randomization analysis with multilayer xQTL data.

Medicine - 5 Jun 2026

Yu Fei, Wan Xiwen, Qiu Jiaxuan

Abstract excerpt

Osteoporosis is a highly heritable metabolic bone disorder characterized by low bone mass and increased fracture risk. However, the causal genes underlying disease susceptibility remain incompletely understood. In this study, we employed a summary-data-based Mendelian randomization (SMR) framework to identify genes with potential causal effects on osteoporosis by integrating genome-wide association study summary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study
Share to Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Docking Simulation

Share to Osteoporosis

Share to Polymorphism, Single Nucleotide

Share to Protein Interaction Maps

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 42260878
DOI: 10.1097/MD.0000000000049116
PMCID: PMC13246085

Genes

CEP112
CKB
GID4
MEOX1
MEPE
RGS9
RSPO3
SERPINA1
SFRP4
SOST
SPP1
TOM1L2
ZBTB48

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causal genes for osteoporosis: Mendelian randomization analysis with multilayer xQTL data.PMID 42260878Read ↗

Genetic insight into the putative causal proteins and druggable targets of osteoporosis: a large-scale proteome-wide mendelian randomization studySemantic proximity Read ↗

PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly.Semantic proximity Read ↗

Causal Relationship Between Blood Metabolites and Osteoporosis: A Two-Sample Mendelian Randomization and Genetic Correlation AnalysisSemantic proximity Read ↗

Causal effect between systemic inflammatory cytokines and osteoporotic pathological fractures: A bidirectional Mendelian randomization study.Semantic proximity Read ↗

MeRP: a high-throughput pipeline for Mendelian randomization analysis.Semantic proximity Read ↗

Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective.Semantic proximity Read ↗

DNA methylation-regulated ZDHHC5 and PPT1 in the pathogenesis of osteoporosis.Semantic proximity Read ↗

Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation.Semantic proximity Read ↗

DMRdb: a disease-centric Mendelian randomization database for systematically assessing causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases.Semantic proximity Read ↗

Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.Semantic proximity Read ↗

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclastsSemantic proximity Read ↗

Pleiotropic genomic variants at 17q21.31 associated with bone mineral density and body fat mass: a bivariate genome-wide association analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.