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Article

Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia.

PloS one - 1 Jan 2018

Schraw Jeremy M, Yiu Teresa T, Lupo Philip J, Tsavachidis Spiridon, Rau Rachel, Bondy Melissa L, Rabin Karen R, Shen Lanlan, Scheurer Michael E

Abstract excerpt

BACKGROUND: There is evidence that maternal genotypes in folate-related genes are associated with pediatric acute lymphoblastic leukemia (ALL) independent of offspring genotype. We evaluated the relationship between maternal genotypes in methionine synthase (MTR) and DNA methylation status in ALL to better characterize the molecular mechanism underlying this association. PROCEDURE: We obtained bone marrow samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29763473
DOI: 10.1371/journal.pone.0197408
PMCID: PMC5953491

Genes

MTR
ETV6
RUNX1

Provenance

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