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Article

Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia.

Human molecular genetics - 28 Oct 2022

Xu Keren, Li Shaobo, Pandey Priyatama, Kang Alice Y, Morimoto Libby M, Mancuso Nicholas, Ma Xiaomei, Metayer Catherine, Wiemels Joseph L, de Smith Adam J

Abstract excerpt

Genome-wide association studies have identified a growing number of single nucleotide polymorphisms (SNPs) associated with childhood acute lymphoblastic leukemia (ALL), yet the functional roles of most SNPs are unclear. Multiple lines of evidence suggest that epigenetic mechanisms may mediate the impact of heritable genetic variation on phenotypes. Here, we investigated whether DNA methylation mediates the effect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35717575
DOI: 10.1093/hmg/ddac137
PMCID: PMC9616572

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