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Article

Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis

14 May 2018

Abstract excerpt

Polymyxin is the last line of defense against severe infections caused by carbapenem-resistant gram-negative pathogens. The emergence of transferable MCR-1/2 polymyxin resistance greatly challenges the renewed interest in colistin (polymyxin E) for clinical treatments. Recent studies have suggested that Moraxella species are a putative reservoir for MCR-1/2 genetic determinants. Here, we report the functional...

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PMID: 29758020
DOI: 10.1371/journal.pgen.1007389

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