Article
EptA of Riemerella anatipestifer mediates phenotypes involved in colistin resistance and virulence.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2023
Chen Qiwei, Quan Heng, Yu Yongfeng, Liu Donghui, Li Caiyu, Chu Yuefeng, Gong Xiaowei
Abstract excerpt
Colistin (polymyxin E) is a group of cationic antimicrobial cyclic peptides and is recognized as a last-resort defense against lethal infections with carbapenem-resistant pathogens. In addition to the plasmid-borne mobilized phosphoethanolamine (PEA) transferases, the functional expression of lipid A-modifying enzymes encoded on chromosomes has been attributed to intrinsic bacterial colistin resistance. However,...
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