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Article

Mechanistic insights into transferable polymyxin resistance among gut bacteria.

The Journal of biological chemistry - 23 Mar 2018

Xu Yongchang, Lin Jingxia, Cui Tao, Srinivas Swaminath, Feng Youjun

Abstract excerpt

Polymyxins such as colistin are antibiotics used as a final line of defense in the management of infections with multidrug-resistant Gram-negative bacteria. Although natural resistance to polymyxins is rare, the discovery of a mobilized colistin resistance gene (mcr-1) in gut bacteria has raised significant concern. As an intramembrane enzyme, MCR-1 catalyzes the transfer of phosphoethanolamine (PEA) to the 1 (or...

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Identifiers

PMID: 29462787
DOI: 10.1074/jbc.RA117.000924
PMCID: PMC5868246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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