Article

Comprehensive proteomic and metabolomic profiling of <i>mcr-1</i> mediated colistin resistance in <i>Escherichia coli</i>

2018-10-03

Abstract excerpt

The spread of mcr-1 in human and veterinary medicine has jeopardized the use of polymyxins, the last-resort antibiotics against life-threatening multidrug-resistant Gram-negative bacteria. As a lipid-modified gene, whether mcr-1 brings proteomic and metabolomic changes in the bacteria and affects the corresponding metabolic pathway is largely unknown. Herein, we used label-free quantitative proteomics and untarg...

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Literature Corpus work: 0b1ef0d1-0284-5cb3-8ad0-10f21d47d597
DOI: 10.1101/434548

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