Article

Identification of a novel MCR-1 variant displaying low level of co-resistance to β-lactam antibiotics that uncovers a potential novel antimicrobial peptide

2023-04-03

Abstract excerpt

The emerging and global spread of a novel plasmid-mediated colistin resistance gene, mcr-1 , threatens human health. It is accepted that MCR-1 affects bacterial fitness, and this fitness cost correlates with bacterial membrane lipid A perturbation. However, the detailed molecular mechanism remains unclear. Here, we screened out a novel MCR-1 variant, named M6, with a two-point mutation that rendered a low level o...

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Literature Corpus work: 8b366dc4-daab-5bdf-8102-65e8353d70c9
DOI: 10.1101/2023.04.03.535341

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Identification of a novel MCR-1 variant displaying low level of co-resistance to β-lactam antibiotics that uncovers a potential novel antimicrobial peptideDOI 10.1101/2023.04.03.535341Read

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