Back to search

Article

Colistin resistance in <i>Escherichia coli</i> confers protection of the cytoplasmic but not outer membrane from the polymyxin antibiotic

2021-07-21

Abstract excerpt

Colistin is a polymyxin antibiotic of last resort for the treatment of infections caused by multi-drug resistant Gram-negative bacteria. By targeting lipopolysaccharide (LPS), the antibiotic disrupts both the outer and cytoplasmic membranes, leading to lysis and bacterial death. Colistin resistance in Escherichia coli occurs via mutations in the chromosome or the acquisition of mobilised colistin resistance ( mc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6b2d6415-8923-55eb-8144-c811dd7ba122
DOI
10.1101/2021.07.21.453182
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Colistin resistance in <i>Escherichia coli</i> confers protection of the cytoplasmic but not outer membrane from the polymyxin antibioticDOI 10.1101/2021.07.21.453182
Colistin resistance in Escherichia coli confers protection of the cytoplasmic but not outer membrane from the polymyxin antibioticSemantic proximity
Non-clonal emergence of colistin resistance associated with mutations in the BasRS two-component system in <i>Escherichia coli</i> bloodstream isolatesSemantic proximity
Colistin Resistance Mechanism and Management Strategies of Colistin-Resistant <em>Acinetobacter baumannii</em> InfectionsSemantic proximity
Harder, better, faster, stronger: Colistin resistance mechanisms in Escherichia coliSemantic proximity
Colistin Resistance Gene mcr-1 Mediates Cell Permeability and Resistance to Hydrophobic AntibioticsSemantic proximity
Understanding Recent Developments in Colistin Resistance: Mechanisms, Clinical Implications, and Future PerspectivesSemantic proximity
Rough-type and loss of the LPS due to lpx genes deletions are associated with colistin resistance in multidrug-resistant clinical Escherichia coli isolates not harbouring mcr genesSemantic proximity
Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in BacteriaSemantic proximity
Towards Understanding MCR-like Colistin Resistance.Semantic proximity
Colistin Resistance Mechanism and Management Strategies of Colistin-Resistant Acinetobacter baumannii InfectionsSemantic proximity
Colistin resistance-mediated lipopolysaccharide modification in <i>Klebsiella pneumoniae</i> modulates host inflammatory responseSemantic proximity
Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and EpidemiologySemantic proximity
Select a neighboring publication to make it the new centre.