Article
IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53.
The Journal of biological chemistry - 22 Jun 2018
Jiang Bin, Zhao Wentao, Shi Minggang, Zhang Jia, Chen Ai, Ma Huanhuan, Suleman Muhammad, Lin Furong, Zhou Lin, Wang Jinyang, Zhang Yan, Liu Mengjue, Wen Shixiong, Ouyang Cong, Wang Huihui, Huang Xiumin, Zhou Huamin, Li Qinxi
Abstract excerpt
Resistance to apoptosis and uncontrolled proliferation are two hallmarks of cancer cells. p53 is crucial for apoptosis triggered by a broad range of stresses and a well-known gatekeeper for neoplastic transformation. Here we show that oncogenic IDH1 R132H/R132Q mutants robustly inhibit p53 expression and such an effect is attributed to 2-HG production. Mechanistically, 2-hydroxyglutarate (2-HG) stabilizes...
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