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Article

Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death.

Apoptosis : an international journal on programmed cell death - 1 Nov 2013

Mohrenz Isabelle Vanessa, Antonietti Patrick, Pusch Stefan, Capper David, Balss Jörg, Voigt Sophia, Weissert Susanne, Mukrowsky Alicia, Frank Jan, Senft Christian, Seifert Volker, von Deimling Andreas, Kögel Donat

Abstract excerpt

Isocitrate dehydrogenase 1 (IDH1) decarboxylates isocitrate to α-ketoglutarate (α-KG) leading to generation of NADPH, which is required to regenerate reduced glutathione (GSH), the major cellular ROS scavenger. Mutation of R132 of IDH1 abrogates generation of α-KG and leads to conversion of α-KG to 2-hydroxyglutarate. We hypothesized that glioma cells expressing mutant IDH1 have a diminished antioxidative...

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Source

Identifiers

PMID: 23801081
DOI: 10.1007/s10495-013-0877-8

Genes

IDH1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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