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Article

IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced.

PloS one - 1 Jan 2017

Zhu Huixia, Zhang Ye, Chen Jianfeng, Qiu Jiangdong, Huang Keting, Wu Mindan, Xia Chunlin

Abstract excerpt

AIM OF STUDY: Mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene were recently discovered in vast majority of World Health Organization (WHO) grade II/III gliomas. This study is to understand the effects of IDH1 R132H mutation in gliomagenesis and to develop new strategies to treat glioma with IDH1 R132H mutation. MATERIALS AND METHODS: Over expression of IDH1 R132H in U87MG cells was done by...

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Identifiers

PMID: 28052098
DOI: 10.1371/journal.pone.0169038
PMCID: PMC5215606

Genes

IDH1
IDH2

Variants

Provenance

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