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Article

Autophagy and oxidative stress in gliomas with IDH1 mutations.

Acta neuropathologica - 1 Feb 2014

Gilbert Misty R, Liu Yinxing, Neltner Janna, Pu Hong, Morris Andrew, Sunkara Manjula, Pittman Thomas, Kyprianou Natasha, Horbinski Craig

Abstract excerpt

IDH1 mutations in gliomas associate with longer survival. Prooxidant and antiproliferative effects of IDH1 mutations and its D-2-hydroxyglutarate (2-HG) product have been described in vitro, but inconsistently observed. It is also unclear whether overexpression of mutant IDH1 in wild-type cells a...

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Source

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Identifiers

PMID: 24150401
DOI: 10.1007/s00401-013-1194-6
PMCID: PMC3946987

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24150401-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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