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Article

Isocitrate dehydrogenase gene variants in cancer and their clinical significance.

Biochemical Society transactions - 17 Dec 2021

Cadoux-Hudson Thomas, Schofield Christopher J, McCullagh James S O

Abstract excerpt

Human isocitrate dehydrogenase (IDH) genes encode for the IDH1, 2 & 3 isoenzymes which catalyse the formation of 2-oxoglutarate from isocitrate and are essential for normal mammalian metabolism. Although mutations in these genes in cancer were long thought to lead to a 'loss of function', combined genomic and metabolomic studies led to the discovery that a common IDH 1 mutation, present in low-grade glioma and...

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Identifiers

PMID: 34854890
DOI: 10.1042/BST20210277
PMCID: PMC8786286

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