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Article

Oncogenic MicroRNA-20a is downregulated by the HIF-1α/c-MYC pathway in IDH1 R132H-mutant glioma.

Biochemical and biophysical research communications - 23 May 2018

Xu Qingfu, Ahmed A Karim, Zhu Yan, Wang Kimberly, Lv Shengqing, Li Yunqing, Jiang Yugang

Abstract excerpt

Mutations in the isocitrate dehydrogenase 1 (IDH1) gene have been identified as one of the earliest events in gliomagenesis, occurring in over 70% of low grade gliomas and are present in the vast majority of secondary glioblastoma (GBM) that develop from these low-grade lesions. The aim of this study was to investigate whether the IDH1 R132H mutation influences the expression of oncogenic miR-20a and shed light...

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Identifiers

PMID: 29625108
DOI: 10.1016/j.bbrc.2018.04.011

Genes

IDH1
MYC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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