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Article

Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.

Clinical pharmacology and therapeutics - 1 Jan 2019

Bhatt Deepak Kumar, Mehrotra Aanchal, Gaedigk Andrea, Chapa Revathi, Basit Abdul, Zhang Haeyoung, Choudhari Prachi, Boberg Mikael, Pearce Robin E, Gaedigk Roger, Broeckel Ulrich, Leeder J Steven, Prasad Bhagwat

Abstract excerpt

The ontogeny of hepatic uridine diphosphate-glucuronosyltransferases (UGTs) was investigated by determining their protein abundance in human liver microsomes isolated from 136 pediatric (0-18 years) and 35 adult (age >18 years) donors using liquid chromatography / tandem mass spectrometry (LC-MS/MS) proteomics. Microsomal protein abundances of UGT1A1, UGT1A4, UGT1A6, UGT1A9, UGT2B7, and UGT2B15 increased by ∼8,...

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Identifiers

PMID: 29737521
DOI: 10.1002/cpt.1109
PMCID: PMC6222000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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