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Article

Sexual dimorphism in metabolomic and phenotypic spectra of UGT deficiency: findings from the Canadian Longitudinal Study on Aging.

Biology of sex differences - 22 Apr 2025

Rivera-Herrera Ana Lucia, Rouleau Michèle, Singbo Mahukpe Narcisse Ulrich, Cuppens Tania, Prunier Julien, Droit Arnaud, Simonyan David, Guillemette Chantal

Abstract excerpt

BACKGROUND: Two of the most frequently deleted genes in the human genome are the UDP-glycosyltransferases UGT2B17 and UGT2B28. They encode metabolic enzymes of the glucuronidation pathway that plays a pivotal role in the maintenance of cellular homeostasis for a variety of small molecule metabolites. These deletions may impact health, yet their effects remain poorly understood. We evaluated the impact of UGT...

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Identifiers

PMID: 40264209
DOI: 10.1186/s13293-025-00708-5
PMCID: PMC12013048

Genes

UGT2B17
UGT2B28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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