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Article

Human hepatic CYP2B6 developmental expression: the impact of age and genotype.

Biochemical pharmacology - 15 Jul 2009

Croom Edward L, Stevens Jeffrey C, Hines Ronald N, Wallace Andrew D, Hodgson Ernest

Abstract excerpt

Although CYP2B6 is known to metabolize numerous pharmaceuticals and toxicants in adults, little is known regarding CYP2B6 ontogeny or its possible role in pediatric drug/toxicant metabolism. To address this knowledge gap, hepatic CYP2B6 protein levels were characterized in microsomal protein preparations isolated from a pediatric liver bank (N=217). Donor ages ranged from 10 weeks gestation to 17 years of age...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Gene Expression Regulation, Enzymologic

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Share to Microsomes, Liver

Share to Oxidoreductases, N-Demethylating

Source

Identifiers

PMID: 19464434
DOI: 10.1016/j.bcp.2009.03.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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