Article
Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2018
Bhatt Deepak Kumar, Basit Abdul, Zhang Haeyoung, Gaedigk Andrea, Lee Seung-Been, Claw Katrina G, Mehrotra Aanchal, Chaudhry Amarjit Singh, Pearce Robin E, Gaedigk Roger, Broeckel Ulrich, Thornton Timothy A, Nickerson Deborah A, Schuetz Erin G, Amory John K, Leeder J Steven, Prasad Bhagwat
Abstract excerpt
The major objective of this study was to investigate the association of genetic and nongenetic factors with variability in protein abundance and in vitro activity of the androgen-metabolizing enzyme UGT2B17 in human liver microsomes (n = 455). UGT2B17 abundance was quantified by liquid chromatography-tandem mass spectrometry proteomics, and enzyme activity was determined by using testosterone and...
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