Article
Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A).
Critical reviews in clinical laboratory sciences - 1 Jan 2008
Strassburg Christian P, Kalthoff Sandra, Ehmer Ursula
Abstract excerpt
The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants, chemotherapeutics, steroid hormones, bile acids, and bilirubin. The unique genetic organization of the human UGT1A gene locus, and an increasing number of functionally relevant genetic variants define tissue specificity as well as a broad range of...
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