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Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A).

Critical reviews in clinical laboratory sciences - 1 Jan 2008

Strassburg Christian P, Kalthoff Sandra, Ehmer Ursula

Abstract excerpt

The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants, chemotherapeutics, steroid hormones, bile acids, and bilirubin. The unique genetic organization of the human UGT1A gene locus, and an increasing number of functionally relevant genetic variants define tissue specificity as well as a broad range of...

Topics

Evolution, Molecular
Gene Components
Genetic Variation
Glucuronosyltransferase
Humans
Hyperbilirubinemia
Molecular Structure
Neoplasms
Pharmaceutical Preparations
Pharmacogenetics
Substrate Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19003600
DOI: 10.1080/10408360802374624

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