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Article

Age-Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling.

Clinical pharmacology and therapeutics - 1 Oct 2024

Parvez Md Masud, Thakur Aarzoo, Mehrotra Aanchal, Stancil Stephani, Pearce Robin E, Basit Abdul, Leeder J Steven, Prasad Bhagwat

Abstract excerpt

The expression of cytochrome P450 (CYP) enzymes is highly variable and associated with factors, such as age, genotype, sex, and disease states. In this study, quantification of metronidazole metabolizing CYP isoforms (CYP2A6, CYP2E1, CYP3A4, CYP3A5, and CYP3A7) in human liver microsomes from 115 children and 35 adults was performed using a quantitative proteomics method. The data confirmed age-dependent increase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38955794
DOI: 10.1002/cpt.3354

Genes

CYP2A6
CYP3A7
CYP2E1
CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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