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Article

Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years.

Clinical pharmacology and therapeutics - 1 May 2020

Zhang Haeyoung, Basit Abdul, Wolford Chris, Chen Kuan-Fu, Gaedigk Andrea, Lin Yvonne S, Leeder J Steven, Prasad Bhagwat

Abstract excerpt

UDP-glucuronosyltransferase 2B17 (UGT2B17) is a highly variable androgen-metabolizing and drug-metabolizing enzyme. UGT2B17 exhibits a unique ontogeny profile characterized by a dramatic increase in hepatic protein expression from prepubertal age to adulthood. Age, sex, copy number variation (CNV), and single nucleotide polymorphisms only explain 26% of variability in protein expression, highlighting the need for...

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PMID: 31900930
DOI: 10.1002/cpt.1764
PMCID: PMC7167343

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