Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation.

Calcified tissue international - 1 Jan 2018

McDonald Michelle M, Morse Alyson, Schindeler Aaron, Mikulec Kathy, Peacock Lauren, Cheng Tegan, Bobyn Justin, Lee Lucinda, Baldock Paul A, Croucher Peter I, Tam Patrick P L, Little David G

Abstract excerpt

Wnt antagonist Dkk1 is a negative regulator of bone formation and Dkk1 +/- heterozygous mice display a high bone mass phenotype. Complete loss of Dkk1 function disrupts embryonic head development. Homozygous Dkk1 -/- mice that were heterozygous for Wnt3 loss of function mutation (termed Dkk1 KO) are viable and allowed studying the effects of homozygous inactivation of Dkk1 on bone formation. Dkk1 KO mice showed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Diseases, Metabolic

Share to Bone Resorption

Share to Intercellular Signaling Peptides and Proteins

Share to Mice, Knockout

Share to Osteogenesis

Share to Phenotype

Source

Identifiers

PMID: 29105022
DOI: 10.1007/s00223-017-0338-4

Genes

DKK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation.PMID 29105022Read ↗

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.Semantic proximity Read ↗

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression.Semantic proximity Read ↗

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.Semantic proximity Read ↗

Increased trabecular bone formation in mice lacking the growth factor midkine.Semantic proximity Read ↗

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.Semantic proximity Read ↗

Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization.Semantic proximity Read ↗

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model.Semantic proximity Read ↗

Generation and Characterization of <i>dickkopf3</i> Mutant MiceSemantic proximity Read ↗

Female LSD1 Conditional Knockout Mice Have an Increased Bone MassSemantic proximity Read ↗

KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regenerationSemantic proximity Read ↗

Loss of Dkk-1 in Osteocytes Mitigates Alveolar Bone Loss in Mice With PeriodontitisSemantic proximity Read ↗

Correlation of serum DKK1 level with skeletal phenotype in children with osteogenesis imperfecta.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.