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Article

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2006

Morvan Frederic, Boulukos Kim, Clément-Lacroix Philippe, Roman Roman Sergio, Suc-Royer Isabelle, Vayssière Béatrice, Ammann Patrick, Martin Patrick, Pinho Sonia, Pognonec Philippe, Mollat Patrick, Niehrs Christof, Baron Roland, Rawadi Georges

Abstract excerpt

UNLABELLED: Wnt/beta-catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast differentiation and mineralized matrix formation. We show that Dkk1, unlike Dkk2, negatively regulates osteoblast differentiation and bone formation. INTRODUCTION: The Wnt co-receptor LRP5 is a critical regulator of bone mass. Dickkopf (Dkk)...

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Identifiers

PMID: 16753024
DOI: 10.1359/jbmr.060311

Genes

LRP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.PMID 16753024Read ↗

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