Article
Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2018
Yee Cristal S, Manilay Jennifer O, Chang Jiun C, Hum Nicholas R, Murugesh Deepa K, Bajwa Jamila, Mendez Melanie E, Economides Aris E, Horan Daniel J, Robling Alexander G, Loots Gabriela G
Abstract excerpt
Sclerostin (Sost) is a negative regulator of bone formation and blocking its function via antibodies has shown great therapeutic promise by increasing both bone mass in humans and animal models. Sclerostin deletion in Sost KO mice (Sost-/- ) causes high bone mass (HBM) similar to sclerosteosis patients. Sost-/- mice have been shown to display an up to 300% increase in bone volume/total volume (BV/TV), relative to...
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