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Article

Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells.

Molecular oncology - 1 Jun 2018

Maturi Varun, Morén Anita, Enroth Stefan, Heldin Carl-Henrik, Moustakas Aristidis

Abstract excerpt

Transcriptional regulation mediated by the zinc finger protein Snail1 controls early embryogenesis. By binding to the epithelial tumor suppressor CDH1 gene, Snail1 initiates the epithelial-mesenchymal transition (EMT). The EMT generates stem-like cells and promotes invasiveness during cancer progression. Accordingly, Snail1 mRNA and protein is abundantly expressed in triple-negative breast cancers with enhanced...

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Identifiers

PMID: 29729076
DOI: 10.1002/1878-0261.12317
PMCID: PMC6026864

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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