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Article

Genome–wide binding of transcription factor ZEB1 in triple‐negative breast cancer cells

10 May 2018

Abstract excerpt

Zinc finger E-box binding homeobox 1 (ZEB1) is a transcriptional regulator involved in embryonic development and cancer progression. ZEB1 induces epithelial-mesenchymal transition (EMT). Triple-negative human breast cancers express high ZEB1 mRNA levels and exhibit features of EMT. In the human triple-negative breast cancer cell model Hs578T, ZEB1 associates with almost 2,000 genes, representing many cellular...

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PMID: 29744893
DOI: 10.1002/jcp.26634

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