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Article

The transcriptional repressor BCL11A promotes breast cancer metastasis

23 Jun 2020

Abstract excerpt

The phenotypes of each breast cancer subtype are defined by their transcriptomes. However, the transcription factors that regulate differential patterns of gene expression that contribute to specific disease outcomes are not well understood. Here, using gene silencing and overexpression approaches, RNA-Seq, and splicing analysis, we report that the transcription factor B-cell leukemia/lymphoma 11A (BCL11A) is...

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PMID: 32576660
DOI: 10.1074/jbc.ra120.014018

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