Article

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer

2021-05-28

Abstract excerpt

Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease, which warrants the critical need to identify new therapeutic targets. We show that Zinc Fingers And Homeoboxes 2 (ZHX2) is amplified or overexpressed in TNBC cell lines and patients. Functionally, depletion of ZHX2 inhibited TNBC cell growth and invasion in vitro, orthotopic tumor growth and spontaneous lung metastasis in vivo. Mechan...

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Literature Corpus work: cbe6fa74-2d6f-5557-b2f5-d0fea8a78ae7
DOI: 10.1101/2021.05.27.445959

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