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Article

LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer.

Oncogene - 1 Nov 2018

Luo Liyun, Tang Hailin, Ling Li, Li Nan, Jia Xiaoting, Zhang Zhijie, Wang Xiaorong, Shi Lejuan, Yin Jiang, Qiu Ni, Liu Hao, Song Ying, Luo Kai, Li Hongsheng, He Zhimin, Zheng Guopei, Xie Xiaoming

Abstract excerpt

Breast cancer is a heterogeneous disease, and triple-negative breast cancer (TNBC) continues to be a serious health problem. The potential involvement of lncRNAs in TNBC progression remains unexplored. Here, we demonstrated that LINC01638 is highly expressed in TNBC tissues and cells. LINC01638 maintains the mesenchymal traits of TNBC cells, including an enriched epithelial-mesenchymal transition (EMT) signature...

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Share to Cell Adhesion Molecules
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-myc

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Source

Identifiers

PMID: 30002443
DOI: 10.1038/s41388-018-0396-8

Genes

MTDH
SPOP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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