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Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention

1 Aug 2014

Abstract excerpt

Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors, which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell differentiation and survival, two processes central in cancer research. Encoded by the SNAI1 gene located on human chromosome 20q13.2, Snail1 is composed of 264 amino acids and usually acts as a transcriptional repressor....

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PMID: 25084828
DOI: 10.1186/s13046-014-0062-0

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