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Article

The Role of Snail in EMT and Tumorigenesis

31 Dec 2013

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a highly conserved process in which polarized, immobile epithelial cells lose tight junctions, associated adherence, and become migratory mesenchymal cells. Several transcription factors, including the Snail/Slug family, Twist, δEF1/ZEB1, SIP1/ZEB2 and E12/E47 respond to microenvironmental stimuli and function as molecular switches for the EMT program. Snail is a...

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Identifiers

PMID: 24168186
DOI: 10.2174/15680096113136660102

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