Article
Prognostic Impact of Breast-Conserving Therapy Versus Mastectomy of BRCA1/2 Mutation Carriers Compared With Noncarriers in a Consecutive Series of Young Breast Cancer Patients.
Annals of surgery - 1 Aug 2019
van den Broek Alexandra J, Schmidt Marjanka K, van 't Veer Laura J, Oldenburg Hester S A, Rutgers Emiel J, Russell Nicola S, Smit Vincent T H B M, Voogd Adri C, Koppert Linetta B, Siesling Sabine, Jobsen Jan J, Westenend Pieter J, van Leeuwen Flora E, Tollenaar Rob A E M
Abstract excerpt
OBJECTIVE: To investigate the effects of different types of surgery on breast cancer prognosis in germline BRCA1/BRCA2 mutation carriers compared with noncarriers. SUMMARY OF BACKGROUND DATA: Although breast-conserving therapy (breast-conserving surgery followed by radiotherapy) has been associated with more local recurrences than mastectomy, no differences in overall survival have been found in randomized trials...
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