Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study.

doi:10.1016/S1470-2045(17)30891-4

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Article

Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study.

The Lancet. Oncology - 1 Feb 2018

Copson Ellen R, Maishman Tom C, Tapper Will J, Cutress Ramsey I, Greville-Heygate Stephanie, Altman Douglas G, Eccles Bryony, Gerty Sue, Durcan Lorraine T, Jones Louise, Evans D Gareth, Thompson Alastair M, Pharoah Paul, Easton Douglas F, Dunning Alison M, Hanby Andrew, Lakhani Sunil, Eeles Ros, Gilbert Fiona J, Hamed Hisham, Hodgson Shirley, Simmonds Peter, Stanton Louise, Eccles Diana M

Abstract excerpt

BACKGROUND: Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The primary aim of this study was to determine the effect of a germline BRCA1 or BRCA2 mutation on breast cancer outcomes in patients with young-onset breast cancer. METHODS: We did a prospective cohort study of female patients recruited from 127...

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PMID: 29337092
DOI: 10.1016/S1470-2045(17)30891-4
PMCID: PMC5805863

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BRCA1
BRCA2

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