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Article

Impact of Aging on the Frequency, Phenotype, and Function of CD161-Expressing T Cells.

Frontiers in immunology - 1 Jan 2018

van der Geest Kornelis S M, Kroesen Bart-Jan, Horst Gerda, Abdulahad Wayel H, Brouwer Elisabeth, Boots Annemieke M H

Abstract excerpt

Immune-aging is associated with perturbed immune responses in the elderly. CD161-expressing T cells, i.e., the previously described subsets of CD161+ CD4+ T cells, CD161high CD8+ T cells, and CD161int CD8+ T cells, are highly functional, pro-inflammatory T cells. These CD161-expressing T cells are critical in immunity against microbes, while possibly contributing to autoimmune diseases. So far, little is known...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29725326
DOI: 10.3389/fimmu.2018.00752
PMCID: PMC5917671

Genes

KLRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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