Article
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation.
The Journal of experimental medicine - 16 Mar 2009
Kleinschek Melanie A, Boniface Katia, Sadekova Svetlana, Grein Jeff, Murphy Erin E, Turner Scott P, Raskin Lisa, Desai Bela, Faubion William A, de Waal Malefyt Rene, Pierce Robert H, McClanahan Terrill, Kastelein Robert A
Abstract excerpt
The C-type lectin-like receptor CD161, which has recently been described to promote T cell expansion, is expressed on a discrete subset of human CD4 T cells. The function of such cells, however, has remained elusive. We now demonstrate that CD161(+) CD4 T cells comprise a circulating and gut-resi...
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