Article
CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.
Cell reports - 6 Nov 2014
Fergusson Joannah R, Smith Kira E, Fleming Vicki M, Rajoriya Neil, Newell Evan W, Simmons Ruth, Marchi Emanuele, Björkander Sophia, Kang Yu-Hoi, Swadling Leo, Kurioka Ayako, Sahgal Natasha, Lockstone Helen, Baban Dilair, Freeman Gordon J, Sverremark-Ekström Eva, Davis Mark M, Davenport Miles P, Venturi Vanessa, Ussher James E, Willberg Christian B, Klenerman Paul
Abstract excerpt
The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To understand whether different T cell subsets expressing CD161 have similar properties, we examined these populations in parallel using mass cytometry and mRNA microarray approaches. The analysis identified a conserved CD161++/MAIT cell...
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