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The quest continues: Human CD4 <sup>+</sup> CD16 <sup>+</sup> CD56 <sup>+</sup> ‘exTreg’ resemble NKT cells instead

2025-08-07

Abstract excerpt

Regulatory T cells are essential for immune tolerance, but their loss of function under inflammatory conditions in murine models signify a risk factor for Treg-based therapies. Recently CD4 + CD56 + CD16 + T cells were suggested to resemble such ex-Treg in human PBMC. Here, we re-evaluate the identity of the CD4 + CD56 + CD16 + population at a phenotypic and transcriptomic level using multiparametric flow cy...

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Literature Corpus work: 59f63148-8061-534f-b116-886edc9b2f70
DOI: 10.1101/2025.08.05.667656

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