Article
Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.
GeroScience - 1 Dec 2019
Walker Edith M, Slisarenko Nadia, Gerrets Giovanni L, Kissinger Patricia J, Didier Elizabeth S, Kuroda Marcelo J, Veazey Ronald S, Jazwinski S Michal, Rout Namita
Abstract excerpt
The development of chronic inflammation, called inflammaging, contributes to the pathogenesis of age-related diseases. Although it is known that both B and T lymphocyte compartments of the adaptive immune system deteriorate with advancing age, the impact of aging on immune functions of Th17-type CD161-expressing innate immune cells and their role in inflammaging remain incompletely understood. Here, utilizing the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.