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Article

Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells.

PloS one - 1 Jan 2013

Shen Hui, Zhang Wei, Abraham Clara, Cho Judy H

Abstract excerpt

The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability in IL-23-induced signal transduction in circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproducible inter-individual differences in IL-23 responsiveness (measured by STAT3 phosphorylation) in peripheral blood...

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Share to B-Lymphocyte Subsets
Share to CD8-Positive T-Lymphocytes
Share to Immunologic Memory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-23

Share to Nuclear Receptor Subfamily 1, Group F, Member 3

Share to Receptors, Interleukin

Share to STAT3 Transcription Factor

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Source

Open in PubMed Open full text

Identifiers

PMID: 23469228
DOI: 10.1371/journal.pone.0057746
PMCID: PMC3585933

Genes

RORC
STAT3
KLRB1
RORA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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