Article
Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes.
Scientific reports - 2 May 2018
Stokowy Tomasz, Polushina Tatiana, Sønderby Ida E, Karlsson Robert, Giddaluru Sudheer, Le Hellard Stephanie, Bergen Sarah E, Sullivan Patrick F, Andreassen Ole A, Djurovic Srdjan, Hultman Christina M, Steen Vidar M
Abstract excerpt
Schizophrenia is a serious psychotic disorder with high heritability. Several common genetic variants, rare copy number variants and ultra-rare gene-disrupting mutations have been linked to disease susceptibility, but there is still a large gap between the estimated and explained heritability. Since several studies have indicated brain myelination abnormalities in schizophrenia, we aimed to examine whether...
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