Article
Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.
Molecular psychiatry - 1 May 2010
Le Hellard S, Mühleisen T W, Djurovic S, Fernø J, Ouriaghi Z, Mattheisen M, Vasilescu C, Raeder M B, Hansen T, Strohmaier J, Georgi A, Brockschmidt F F, Melle I, Nenadic I, Sauer H, Rietschel M, Nöthen M M, Werge T, Andreassen O A, Cichon S, Steen V M
Abstract excerpt
Several studies have reported structural brain abnormalities, decreased myelination and oligodendrocyte dysfunction in schizophrenia. In the central nervous system, glia-derived de novo synthesized cholesterol is essential for both myelination and synaptogenesis. Previously, we demonstrated in glial cell lines that antipsychotic drugs induce the expression of genes involved in cholesterol and fatty acids...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.