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Article

Dysregulation of myelination-related genes in schizophrenia.

Journal of neurochemistry - 1 Sept 2024

Bergstrom Johanna J D, Fu Meng-Meng

Abstract excerpt

Schizophrenic individuals display disrupted myelination patterns, altered oligodendrocyte distribution, and abnormal oligodendrocyte morphology. Schizophrenia is linked with dysregulation of a variety of genes involved in oligodendrocyte function and myelin production. Single-nucleotide polymorphisms (SNPs) and rare mutations in myelination-related genes are observed in certain schizophrenic populations,...

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Myelin Proteins
Myelin Sheath
Oligodendroglia
Polymorphism, Single Nucleotide
Schizophrenia

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PMID: 39086020
DOI: 10.1111/jnc.16152
PMCID: PMC11449665

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