Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance.

doi:10.1002/ajmg.b.32597

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Article

Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2017

Kos Mark Z, Carless Melanie A, Peralta Juan, Curran Joanne E, Quillen Ellen E, Almeida Marcio, Blackburn August, Blondell Lucy, Roalf David R, Pogue-Geile Michael F, Gur Ruben C, Göring Harald H H, Nimgaonkar Vishwajit L, Gur Raquel E, Almasy Laura

Abstract excerpt

Schizophrenia is a serious mental illness, involving disruptions in thought and behavior, with a worldwide prevalence of about one percent. Although highly heritable, much of the genetic liability of schizophrenia is yet to be explained. We searched for susceptibility loci in multiplex, multigenerational families affected by schizophrenia, targeting protein-altering variation with in silico predicted functional...

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PMID: 28902459
DOI: 10.1002/ajmg.b.32597
PMCID: PMC5760172

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