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Article

Myelination-related genes are associated with decreased white matter integrity in schizophrenia.

European journal of human genetics : EJHG - 1 Mar 2016

Chavarria-Siles Ivan, White Tonya, de Leeuw Christiaan, Goudriaan Andrea, Lips Esther, Ehrlich Stefan, Turner Jessica A, Calhoun Vince D, Gollub Randy L, Magnotta Vincent A, Ho Beng-Choon, Smit August B, Verheijen Mark H G, Posthuma Danielle

Abstract excerpt

Disruptions in white matter (WM) tract structures have been implicated consistently in the pathophysiology of schizophrenia. Global WM integrity--as measured by fractional anisotropy (FA)--is highly heritable and may provide a good endophenotype for genetic studies of schizophrenia. WM abnormalities in schizophrenia are not localized to one specific brain region but instead reflect global low-level decreases in...

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Source

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Identifiers

PMID: 26014434
DOI: 10.1038/ejhg.2015.120
PMCID: PMC4757770

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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