Article
Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia.
American journal of human genetics - 10 Aug 2012
Need Anna C, McEvoy Joseph P, Gennarelli Massimo, Heinzen Erin L, Ge Dongliang, Maia Jessica M, Shianna Kevin V, He Min, Cirulli Elizabeth T, Gumbs Curtis E, Zhao Qian, Campbell C Ryan, Hong Linda, Rosenquist Peter, Putkonen Anu, Hallikainen Tero, Repo-Tiihonen Eila, Tiihonen Jari, Levy Deborah L, Meltzer Herbert Y, Goldstein David B
Abstract excerpt
Schizophrenia is a severe psychiatric disorder with strong heritability and marked heterogeneity in symptoms, course, and treatment response. There is strong interest in identifying genetic risk factors that can help to elucidate the pathophysiology and that might result in the development of improved treatments. Linkage and genome-wide association studies (GWASs) suggest that the genetic basis of schizophrenia...
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