Article

Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disorders

2016-08-16

Abstract excerpt

By meta-analyzing rare coding variants in whole-exome sequences of 4,264 schizophrenia cases and 9,343 controls, de novo mutations in 1,077 trios, and array-based copy number variant calls from 6,882 cases and 11,255 controls, we show that individuals with schizophrenia carry a significant burden of rare damaging variants in a subset of 3,230 “highly constrained” genes previously identified as having near-complet...

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Literature Corpus work: f4f99062-bbda-54f6-a110-8d018c3fee1c
DOI: 10.1101/069344

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