Article
Accumulation of minor alleles and risk prediction in schizophrenia.
Scientific reports - 15 Sept 2017
He Pei, Lei Xiaoyun, Yuan Dejian, Zhu Zuobin, Huang Shi
Abstract excerpt
Schizophrenia is a common neuropsychiatric disorder with a lifetime risk of 1%. Accumulation of common polygenic variations has been found to be an important risk factor. Recent studies showed a role for the enrichment of minor alleles (MAs) of SNPs in complex diseases such as Parkinson's disease. Here we similarly studied the role of genome wide MAs in schizophrenia using public datasets. Relative to matched...
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