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Article

Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein.

Cell - 9 Jan 1998

Gleeson J G, Allen K M, Fox J W, Lamperti E D, Berkovic S, Scheffer I, Cooper E C, Dobyns W B, Minnerath S R, Ross M E, Walsh C A

Abstract excerpt

X-linked lissencephaly and "double cortex" are allelic human disorders mapping to Xq22.3-Xq23 associated with arrest of migrating cerebral cortical neurons. We identified a novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predi...

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PMID: 9489700
DOI: 10.1016/s0092-8674(00)80899-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9489700-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein.PMID 9489700Read ↗

Genes that regulate neuronal migration in the cerebral cortex.Semantic proximity Read ↗

A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome.Semantic proximity Read ↗

Doublecortin Is the Major Gene Causing X-Linked Subcortical Laminar Heterotopia (SCLH)Semantic proximity Read ↗

Doublecortin mutations cluster in evolutionarily conserved functional domains.Semantic proximity Read ↗

Somatic and germline mosaic mutations in the doublecortin gene are associated with variable phenotypes.Semantic proximity Read ↗

Classical lissencephaly and double cortex (subcortical band heterotopia): LIS1 and doublecortin.Semantic proximity Read ↗

Somatic mosaicism and variable penetrance in doublecortin-associated migration disorders.Semantic proximity Read ↗

Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis.Semantic proximity Read ↗

The DCX-domain tandems of doublecortin and doublecortin-like kinase.Semantic proximity Read ↗

A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.Semantic proximity Read ↗

Identification of neurabin II as a novel doublecortin interacting protein.Semantic proximity Read ↗

New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum.Semantic proximity Read ↗

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